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. 2020 Oct 12;11:5129. doi: 10.1038/s41467-020-18860-4

Fig. 7. Zeb1 expression is positively correlated with enhanced Notch1 activity in aggressive human breast cancer.

Fig. 7

a Representative images of immunohistochemical staining of Zeb1, NICD, and ALDH1 in serial sections of the same tumor (n = 175). Scale bars, 50 μm. b A positive correlation between the expression of Zeb1 and NICD in the 175 human breast cancer samples. c A positive correlation between the expression of Zeb1 and ALDH1 in breast cancer. d A positive correlation between the expression of NICD and ALDH1 in breast cancer. e Concomitantly high expression of Zeb1 and NICD in poorly differentiated high-grade breast cancer. f, g A strong correlation between high expression of Zeb1 (f) and NICD (g) in the TNBC subtype of breast cancer. Indicated P-values were calculated using Spearman’s rank correction test in bd or Kruskal–Wallis test in e or Kolmogorov–Smirnov test in f, g. Source data are provided as a Source Data file.