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. 2020 Oct 12;10:16992. doi: 10.1038/s41598-020-74083-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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OGT inhibitor OSMI-1 induces transcriptional program indicative of chromatin silencing in tamoxifen-sensitive breast cancer cells. (A) KEGG^55–57 pathway enrichment analysis for the mRNAs that were upregulated exclusively in TamS (Log2(FC) atleast ± 0.5). (B) Histone gene expression in TamS and TamR cells after OGT inhibition with 40 μM OSMI-1 for 24 h representing an average of three biological replicate experiments analyzed using microarrays. (C) Fold change in the expression of all detected histone genes after OGT inhibition in TamS and TamR cells (average of three biological replicate experiments analyzed using microarrays).