Table 1.
Strain information and minimum inhibitory concentrations (MIC) of polymyxin B and resveratrol against bacterial isolates in this study
| Isolate | Source | MIC | Polymyxin susceptibility and mechanism of resistance | ||||
|---|---|---|---|---|---|---|---|
| Res | PB | PB in the presence of 32 μg/ml Res | PB in the presence of 64 μg/ml Res | PB in the presence of 128 μg/ml Res | |||
| Klebsiella pneumoniae | |||||||
| 1 | human | 512 | 16 | 8 | 4 | 2 | mcr-1 |
| 2 | human | 512 | > 512 | > 512 | 128 | 2 | Uncharacterized |
| 3 | human | 512 | 8 | 2 | 2 | 2 | Uncharacterized |
| 4 | human | > 2048 | 4 | 2 | 1 | 1 | Uncharacterized |
| 5 | human | > 2048 | 4 | 2 | 1 | 1 | Uncharacterized |
| 6 | human | 512 | > 512 | > 512 | 256 | 8 | Uncharacterized |
| 7 | human | 1024 | 8 | 2 | 2 | 2 | Uncharacterized |
| 8 | human | > 2048 | > 512 | 256 | 16 | 1 | Uncharacterized |
| 9 | human | 2048 | 4 | 1 | 0.5 | 1 | Uncharacterized |
| 10 | human | 2048 | 4 | 1 | 1 | 1 | Uncharacterized |
| 11 | human | 512 | 4 | 2 | 2 | 1 | Uncharacterized |
| 12 | human | > 2048 | 16 | 1 | 1 | 1 | Uncharacterized |
| 13 | human | 2048 | 4 | 2 | 0.5 | 1 | Uncharacterized |
| 14 | human | 2048 | 4 | 2 | 1 | 1 | Uncharacterized |
| 15 | human | 2048 | 16 | 4 | 2 | 1 | Uncharacterized |
| 16 | human | 2048 | 32 | 4 | 4 | 0.5 | Uncharacterized |
| 17 | human | 2048 | 64 | 16 | 4 | 1 | Uncharacterized |
| 18 | human | 512 | 4 | 1 | 0.5 | 0.5 | Uncharacterized |
| 19 | human | > 2048 | 4 | 1 | 0.5 | 0.5 | Uncharacterized |
| 20 | human | 512 | 256 | 128 | 32 | 1 | Uncharacterized |
| 21 | human | 2048 | 16 | 2 | 2 | 0.5 | Uncharacterized |
| 22 | human | > 2048 | 2 | 0.5 | 0.5 | 1 | Susceptible |
| 23 | human | 512 | 2 | 1 | 0.5 | 1 | Susceptible |
| 24 | human | 2048 | 2 | 2 | 0.5 | 0.5 | Susceptible |
| 25 | human | > 2048 | 2 | 1 | 0.5 | 1 | Susceptible |
| 26 | human | > 2048 | 2 | 1 | 1 | 1 | Susceptible |
| Escherichia coli | |||||||
| 27 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 28 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 29 | animal | 2048 | > 512 | 64 | 8 | 4 | mcr-1 |
| 30 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 31 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 32 | animal | > 2048 | > 512 | > 512 | 256 | 32 | mcr-1 |
| 33 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 34 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 35 | animal | 2048 | 4 | 4 | 2 | 1 | mcr-1 |
| 36 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 37 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 38 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 39 | animal | > 2048 | > 512 | > 512 | 128 | 8 | mcr-1 |
| 40 | animal | 2048 | 32 | 16 | 4 | 1 | mcr-1 |
| 41 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 42 | animal | > 2048 | 4 | 2 | 2 | 1 | mcr-1 |
| 43 | animal | > 2048 | > 512 | > 512 | 256 | 2 | mcr-1 |
| 44 | animal | > 2048 | 4 | 2 | 2 | 0.5 | mcr-1 |
| 45 | animal | 2048 | 64 | 4 | 4 | 0.5 | mcr-1 |
| 46 | animal | > 2048 | 4 | 2 | 2 | 0.5 | mcr-1 |
| 47 | human | 2048 | 4 | 1 | 0.5 | 0.5 | mcr-1 |
| 48 | human | > 2048 | 4 | 2 | 1 | 1 | mcr-1 |
| 49 | animal | 2048 | 32 | 8 | 2 | 1 | Uncharacterized |
| 50 | human | 2048 | 2 | 2 | 1 | 1 | Susceptible |
PB Stands for polymyxin B and Res stands for resveratrol