Table 5.
Potential clinical application of ncRNAs function as ceRNAs in HCC
| ncRNA as ceRNA | Location | Clinical application | Description | Ref |
|---|---|---|---|---|
| circRNA_104075# | Serum | Diagnosis | AUC: 0.973, Se: 96.0%, Sp: 98.3% | [108] |
| BCYRN 1* | Serum | Diagnosis, prognosis, potential therapeutic target | Diagnosis: AUC: 0.7834, Se: 62.10%, Sp: 90.54%; Prognosis: overexpression associates with worse prognosis | [159, 160] |
| lncRNA-RP11‐513I15.6, miR‐1262, RAB11A† | Serum | Diagnosis | AUC: NA, Se: 100%, Sp: 76.7% | [156] |
| OCT4-pg4^ | Tissue | Prognosis, potential therapeutic target | Associates with prognosis | [10] |
| HOXD-AS1* | Tissue | Prognosis, potential therapeutic target | Associates with TNM stage and prognosis | [72] |
| SNHG6-003* | Tissue | Prognosis, potential therapeutic target | Associates with portal vein tumor thrombus, BCLC stage, distant metastasis and prognosis | [85] |
| AGAP2-AS1* | Tissue | Prognosis, potential therapeutic target | Associates with tumor size, histological grade, TNM stage, venous invasion and prognosis | [89] |
| CASC2* | Tissue | Prognosis, potential therapeutic target | Associates with venous infiltration, histological grade, TNM stage and prognosis | [98] |
| circRNA_104718# | Tissue | Prognosis, potential therapeutic target | Associates with vascular invasion and prognosis | [107] |
| circ_0000517# | Tissue | Prognosis, potential therapeutic target | Associated with tumor size, TNM stage, lymph node metastasis and prognosis | [127] |
| circNFATC3# | Tissue | Prognosis, potential therapeutic target | Associates with vascular invasion, histological grade and prognosis | [128] |
| MYCNOS, DLX6-AS1, LINC00221, CRNDE* | Tissue | Prognosis | Associates with prognosis | [161] |
| 13 lncRNAs prognositc model† | Tissue | Prognosis | Associates with prognosis | [162] |
| 3 lncRNAs and 6mRNAs prognostic model† | Tissue | Prognosis | Associates with prognosis | [163] |
ncRNA: non-coding RNA; ceRNA: competing endogenous RNA; HCC: hepatocellular carcinoma; AUC: Area under the curve; Se: Sensitivity; Sp: Specificity; NA: Not available; BCLC: Barcelona Clinic Liver Cancer; Ref: reference
* Long non-coding RNA; #circular RNA; ^ pseudogene; †ceRNA panel