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. 2020 Oct 13;51:128. doi: 10.1186/s13567-020-00850-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Enrichment analyses based on the DAVID database, aimed at discovering the biological meaning of representative up- and down-regulated signalling pathways following PRRSV infection. A–G Whole GCN network (A), 3 dpi-specific network (cluster 1; B and E), lung-specific network (clusters 2 and 3; C and F), and BLN-specific network (clusters 4 and 5; D and G) were used for the analyses. KEGG-enriched pathways for the whole GCN network (A) and each specific network (B–D) were visualised by generating bubble and bar plots. A bubble plot corresponding to the whole network was generated for each analysis for the up-regulated (red) and down-regulated genes (blue) (A).

Data information: Significantly enriched pathways represented in the plots met the following cut-off criterion: − log₁₀ P value > 1.0. GO treemaps were created based on the P values associated with the BP terms for each specific network (E–G).