Table 2.

Alignment of ACE2 sequences and comparison among residues involved in the contact with SARS-CoV-2 RBD. Points mean that the amino acid is identical to the corresponding amino acid in the hACE2 sequence.

ACE2	Amino Acid Position
	19	24	27	28	30	31	34	35	37	38	41
Homo sapiens	S	Q	T	F	D	K	H	E	E	D	Y
Felis catus	.	L	.	.	E	.	.	.	.	E	.
Canis lupus familiaris	.	L	.	.	E	.	Y	.	.	E	.
Oryctolagus cuniculus	.	L	.	.	E	.	Q	.	.	.	.
Ochotona princeps	.	L	.	.	.	.	Q	.	.	.	.
Cricetulus griseus	.	.	.	.	.	.	Q	.	.	.	.
Mesocricetus auratus	.	.	.	.	.	.	Q	.	.	.	.
Mus musculus	.	N	.	.	N	N	Q	.	.	.	.
Rattus norvegicus	.	K	S	.	N	.	Q	.	.	.	.
Mustela putorius furio	.	L	.		E	.	Y	.	.	E	.
ACE2	Amino Acid Position
	42	45	79	82	83	330	353	354	355	357	393
Homo sapiens	Q	L	L	M	Y	N	K	G	D	R	R
Felis catus	.	.	.	T	.	.	.	.	.	.	.
Canis lupus familiaris	.	.	.	T	.	.	.	.	.	.	.
Oryctolagus cuniculus	.	.	.	T	.	.	.	.	.	.	.
Ochotona princeps	.	.	.	T	.	.	.	D	.	.	.
Cricetulus griseus	.	.	.	N	.	.	.	.	.	.	.
Mesocricetus auratus	.	.	.	N	.	.	.	.	.	.	.
Mus musculus	.	.	T	S	F	.	H	.	.	.	.
Rattus norvegicus	.	.	I	N	F	.	H	.	.	.	.
Mustela putorius furio	.	.	H	T	.	.	.	R	.	.	.