Table 3.
Selected case reports of COVID-19 neurologic involvement in neonates and children.
| Neonates (n) | Age | Presenting Symptoms | SARS-CoV-2 Testing | SARS-CoV-2 CSF | Reference |
|---|---|---|---|---|---|
| 5 | <3 y | Hypotonia, drowsiness | NP + | 4/4 - | [71] |
| 1 | 26 d | Upward eye deviation, stiffening | NP + Blood, cEEG, HUS - |
NR | [72] |
| 1 | 1 d | Lethargy, encephalopathy | NP +, rectal + | - | [73] |
| 1 | 6 w | Upward eye deviation, leg stiffening | NP + | - | [74] |
| 1 | 11 y | Seizure | NP + | NR | [75] |
| 1 | 3 d | Irritability, hypertonia | Brain MRI + (transient gliosis of periventricular white matter and subcortical structures) | - | [24] |
Abbreviation: y, years; d, days; w, weeks; NP, nasopharyngeal; cEEG, continuous electroencephalography; HUS, head ultrasound; MRI, magnetic resonance imaging; NR, not reported; +, positive; -, negative.