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. 2020 Jul 2;7(3):67. doi: 10.3390/bioengineering7030067

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The expression of healing-promoting cytokines (VEGF, FGF2, HGF, and KGF) (A), selected tissue-remodeling-associated factors (Collagen I and IV, metalloproteinase (MMP)-2, and MMP-9) (B), and immunomodulatory cytokines (TGFβ, IL-6, and IL-8) (C). ASCs in compared to human skin fibroblasts (HSFs), both cultured for 3 weeks on Integra^®DRT matrix. HSFs were harvested from the same donor as ASCs and were used as reference. The transcription profiles of the selected genes are presented as a fold change of relative mRNA levels in ASCs to relative mRNA level in HSFs. The black horizontal line is placed at fold change 1.0. Legend: d1, donor1; d2, donor 2; d3, donor 3.