Table 1.
Red Blood Cell rigidity in healthy and diabetic subjects as measured in previous Atomic Force Microscopy experiments.
| References | Subjects | Average E (kPa) | Rate | Preparation |
|---|---|---|---|---|
| Lekka et al. (2005) | N = 13 Healthy subjects ramya N = 19 Diabetes Mellitus | 4.9 ± 0.5 ramya 11.3 ± 1.5 (Estimated from the paper) | Not indicated | Dried cells (not fixed) |
| Girasole et al. (2012) | Healthy subjects (number not reported) | Ranges between 75–115 KPa | Not indicated | Fixed cells |
| Gillies and Prestidge (2004) | Healthy subjects (number not reported) | Ranges between 1, 27–7, 22 | Ranges between 0.6–2.8 μm/s | Cells resuspended in PBS solution. Not Fixed |
| Dulińska et al. (2006) | Healthy subjects (number not reported) | 26 | Not indicated | Fixed cells (0.5% glutaraldehyde) resuspended in PBS |
| Li et al. (2012) | Healthy subjects (number not reported) | Ranges between 0.1–0.2 | Not indicated | Cells resuspended in Hank's balanced salt solution (HBSS). Not Fixed |
| Maciaszek and Lykotrafitis (2011) | Healthy subjects (Number not reported) | Monomodal distribution peaked at 1.1 ± 0.4 | Not indicated | Cells resuspended in PBS solution. Not fixed |
| Lamzin and Khayrullin (2014) | N = 40 Healthy subjects | 1.81 ± 0.4 | Not indicated | Dried cells. Not Fixed |
| Zhang et al. (2015) | N = 10 Healthy subjects ramya N = 10 Diabetes mellitus | 0.31 ± 0.03 ramya 24.83 ± 0.61 | Not indicated | Cells resuspended in Hank's balanced salt solution (HBSS). Not Fixed |
| Barns et al. (2017) | N = 4 Healthy subjects | 7.57 ± 3.25 | 1 μm/s | Fixed cells (1.0% glutaraldehyde) resuspended in PBS |
| Fornal et al. (2006) | N = 8 Healthy subjects ramya N = 7 Diabetes mellitus | 4.4 ramya 14.4 | Not Available | Not Available |
| Ciasca et al. (2015) | N = 10 Healthy subjects ramya N = 5 Diabetes mellitus | 1.82 ± 0.20 ramya 2.52 ± 0.58 | 5 μm/s ramya 5 μm/s | Cells resuspended in PBS solutions. Not Fixed |
| Measured in Pretorius et al. (2015) and reviewed in Loyola-Leyva et al. (2018) | N = 25 Healthy subjects ramya N = 69 Diabetes mellitus | 46710 ± 39210 ramya 56483 ± 6418 | QNM frequency between 430 and 516 kHz | Fixed cells (formaldehyde followed by a dehydration) |