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. 2020 Sep 29;8:580367. doi: 10.3389/fcell.2020.580367

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Copyright © 2020 Deng, Chen, Liu, Cai, Wan, Zhang, Fan, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of YTHDF2 leads to abnormal gene expression at the 8-cell stage embryo. (A) Heatmap revealed 1944 genes upregulated and 2771 genes downregulated at the 8-cell stage YTHDF2 knocked down embryos. (B,C) Density plot of fold change of the downregulated and upregulated genes in YTHDF2 knocked down embryos at the 8-cell stage. (D,E) The GO and KEGG enrichment analysis of the DEGs in cluster 2 in YTHDF2 knocked down embryos. (F) The DEGs were enriched in non-coding RNA metabolic process, translational initiation, ribosome, and melanogenesis, as revealed by gene set enrichment analysis.