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. 2020 Sep 29;8:580367. doi: 10.3389/fcell.2020.580367

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Copyright © 2020 Deng, Chen, Liu, Cai, Wan, Zhang, Fan, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of YTHDF2 disturbs maternal mRNAs clearance. (A) Heatmap of the differentially expressed maternal mRNAs in YTHDF2 knockdown embryos at the 8-cell stage. (B) The differentially expressed maternal mRNAs were enriched in RNA splicing and histone methylation items, as revealed by GO enrichment analysis. (C) KEGG enrichment analysis revealed that the differentially expressed maternal mRNAs were enriched in spliceosome, RNA transport, and base excision repair. (D,E) Volcano plot of the DEGs in ZGA-dependent maternal mRNA clearance (Z-decay) and maternally encoded mRNA decay genes (M-decay). (F) Boxplot of FPKM of maternal mRNAs, such as KDM5B, LSD1, and ZP3, in YTHDF2 knockdown embryos at the 8-cell stage.