Table 2.
List of few ongoing clinical trials for skeletal tissue.
| Condition | NCT Identifier | Title | Status | Intervention |
|---|---|---|---|---|
| Non Union Fracture | NCT03325504 | A Comparative Study of 2 Doses of BM Autologous H-MSC + Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union | Recruiting | Biological: Cultured Mesenchymal Stem Cells Procedure: Autologous iliac crest graft |
| Osteochondral Fracture of Talus | NCT03905824 | The Effectiveness of Adding Allogenic Stem Cells After Traditional Treatment of Osteochondral Lesions of the Talus | Recruiting | Biological: Allogenic stromal mesenchymal cells derived from the umbilical cord Procedure: Debridement and microfracture |
| Full Thickness Rotator Cuff Tear | NCT02484950 | Mesenchymal Stem Cell Augmentation in Patients Undergoing Arthroscopic Rotator Cuff Repair | Recruiting | Biological: Mesenchymal stem cell augmentation in rotator cuff repair Procedure: Standard arthroscopic rotator cuff repair |
| Rotator Cuff Tear Rotator Cuff Tendinitis |
NCT03752827 | Autologous Adult Adipose-Derived Regenerative Cell Injection into Chronic Partial-Thickness Rotator Cuff Tears | Recruiting | Device: Adipose Derived Regenerative Cells Drug: Corticosteroid |
| Rotator Cuff Tear | NCT03688308 | Bone Marrow Derived Stem Cells for the Treatment of Rotator Cuff Tears | Recruiting | Procedure: Arthroscopic rotator cuff repair with bone marrow aspirate concentrate |
| Rotator Cuff Tear | NCT03551509 | LifeNet: Extracellular Matrix Graft in Rotator Cuff Repair | Recruiting | Biological: ArthroFLEX ECM scaffold graft Procedure: Control Biological: Crossover |
| Rotator Cuff Tears | NCT04325789 | Rotator Cuff Healing Using a Nanofiber Scaffold in Patients Greater Than 55 Years | Recruiting | Device: Rotium nanofiber graft |
| ACL—Anterior Cruciate Ligament Rupture | NCT03294720 | BioACL Reconstruction with Amnion Collagen Matrix Wrap and Stem Cells Case Series | Active, not recruiting | Procedure: Bio-ACL Device: amnion wrap and BMAC |
| ACL—Anterior Cruciate Ligament Rupture | NCT03294759 | Bio ACL Reconstruction Amnion Collagen Matrix Wrap and Stem Cells | Active, not recruiting | Other: Bio ACL Other: Control |
| Anterior Cruciate Ligament Tear | NCT02664545 | Bridge-Enhanced ACL Repair vs. ACL Reconstruction | Active, not recruiting | Device: BEAR Scaffold Procedure: Tendon Graft |
| Defect of Articular Cartilage Cartilage Injury Osteoarthritis, Knee |
NCT02696876 | Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair | Recruiting | Device: Arthroscopic synovial brushing Procedure: Microfracture |
| Degenerative Lesion of Articular Cartilage of Knee | NCT02090140 | Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects | Recruiting | Procedure: ADSC Application Procedure: Microfracture |
| Osteoarthritis, Knee | NCT04205656 | Prospective Evaluation of PRP and BMC Treatment to Accelerate Healing After ACL Reconstruction | Recruiting | Biological: Leukocyte-Poor Platelet Rich Plasma (LP-PRP) Biological: Bone Marrow Concentrate (BMC) Other: Control group (Placebo) |
| Osteoarthritis, Knee | NCT02805855 | Autologous Culture Expanded Mesenchymal Stromal Cells for Knee Osteoarthritis | Recruiting | Drug: Autologous Adipose-Derived Mesenchymal Stromal Cells |
| Knee Osteoarthritis | NCT03014401 | The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis | Recruiting | Procedure: Arthroscopic debridement with stem cell transplantation Procedure: Arthroscopic debridement only |
| Osteoarthritis, Knee Knee Pain |
NCT03467919 | The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis | Recruiting | Procedure: Micro Fragmented Adipose Tissue Procedure: Corticosteroid injection |
| Post-Traumatic Osteoarthritis of Knee | NCT04222140 | Early Regenerative Intervention for Post-Traumatic Osteoarthritis | Not yet recruiting | Combination Product: ERIPTO Protocol Biological: BMAC Only |
| Knee Osteoarthritis | NCT04043819 | Evaluation of Safety and Exploratory Efficacy of an Autologous Adipose-derived Cell Therapy Product for Treatment of Single Knee Osteoarthritis | Active, not recruiting | Drug: PSC-01 |
| Musculoskeletal Pain Knee Osteoarthritis Cartilage Injury Cartilage Degeneration |
NCT03477942 | Impact of Mesenchymal Stem Cells in Knee Osteoarthritis | Recruiting | Biological: Autologous Mesenchymal Stem Cells |
| Articular Cartilage Disorder of Knee Articular Cartilage; Degeneration |
NCT03101163 | Efficacy and Safety Study of Intra-Articular Injections of Autologous Peripheral Blood Stem Cells Following Subchondral Drilling Surgery for the Treatment of Articular Cartilage Injury in the Knee | Recruiting | Biological: Autologous peripheral blood stem cells and hyaluronic acid Other: Hyaluronic acid |
| Osteoarthritis, Hip | NCT03608579 | Autologous Culture Expanded Adipose Derived MSCs for Treatment of Painful Hip OA | Recruiting | Drug: Autologous Adipose Derived Mesenchymal Stromal Cells |
| Osteoarthritis | NCT03818737 | Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) | Recruiting | Biological: Autologous Bone Marrow Concentrate (BMAC) Biological: Adipose-derived Stromal Vascular Fraction (SVF) Biological: Umbilical Cord Tissue Drug: Depomedrol and Normal saline (Corticosteroid injection) |