Table 4:

Reasons for discontinuation (% patients who discontinued)

	All patients	Age <65 years	del(17p13) present	RESONATE-2 published data
Discontinuation rate	24% (94 events/ 391 total)	23% (36 events/ 159 total )	33% (35 events/ 110 total)	12.5% (17 events/ 135 total)
Median time to discontinuation	6.5 months	11.5 months	6.25 months	Not reported
Reasons for discontinuation As (%) of all discontinuation events
Toxicity / AEs	59.5%	55.5%	40%	64.7% (11/17)
CLL progression	12.8%	16.6%	14.2%	11.8% (2/17)
Transformation	9.6%	11.1%	25.7%	0%
Patient preference	7.4%	2.8%	2.9%	5.9% (1/17)
Death not secondary to CLL or AE	3.2%	2.8%	0%	17.6% (3/17)
Other	3.2%	2.8%	5.7%	0%
Allo-SCT	2.1%	5.6%	5.7%	0%
CAR-T	1.1%	2.8%	2.9%	0%
Cost	1.1%	0%	2.9%	0%
Second malignancy	0%	0%	0%	0%