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. 2020 Sep 22;1(2):zqaa018. doi: 10.1093/function/zqaa018

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© The Author(s) 2020. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 10. — Predicted Impact of Metabolic Dysfunction in Resting Systolic Mechanical Function. The multiscale computational model of myocardial mechanoenergetic coupling was used to predict the effects of changing metabolic status of the myocardium on cardiac mechanical function. (A) The effect of switching the parameterization of the component of the model representing metabolic function for each control sham rat to values of mitochondrial capacity and metabolic pools associated with the mean TAC rat. Predicted EF drop from 67% for the original data to 50% for sham rats with TAC metabolism. (B) The effect of switching the parameterization of the component of the model representing metabolic function for each TAC rat to values of mitochondrial capacity and metabolic pools associated with the mean sham rat. Predicted EF increase from 46% for the original data to 59% for TAC rats with sham metabolism.