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. 2020 Sep 29;10:1685. doi: 10.3389/fonc.2020.01685

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Copyright © 2020 Yang, Zhang, Ye, Mou, Chen, Ou, Xu, Wu, Cheng, Hu, Zou and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGF18 overexpression inhibits ccRCC progression via the EMT process through PI3K/Akt signaling pathway. (A) GSEA was performed to identify pathways between FGF18 high expression ccRCC tissues and low expression ccRCC tissues. (B) EMT was involved in the FGF18 high expression group. (C) Western blotting analysis of protein expression of EMT and PI3K/Akt signal pathway in NC and FGF18 overexpressed 786-O cell. (D) Western blotting analysis of protein expression of EMT and PI3K/Akt signal pathway in NC and FGF18 overexpressed 769-P cell. (E) Western blotting analysis of protein expression of EMT and PI3K/Akt signal pathway in NC and FGF18 overexpressed 786-O cell xenograft mice model.