Table 1.

Role of ion channels in regulating Wnt pathway activity in cancers.

(C) Cancers Type	Models	Channels	Effect of channels expression/activity on Wnt pathway	Mechanism	Expression in cancers	References
Colorectal Cancer	Cell lines, Rat colonic crypts	KCNQ1	↓ Wnt activity Wnt target genes	Stabilization of β-cat. at the plasma membrane	Down	Rapetti-Mauss et al., 2017
Hepatocellular Carcinoma	Cell lines	KCNQ1	↓ Wnt activity	Stabilization of β-cat at the plasma membrane	Down	Fan et al., 2018,
Breast cancer	Mouse models, Cell lines	hERG	↓ Wnt activity (Channel opened)	Stabilization of β-cat at the plasma membrane	Up	Breuer et al., 2019
Colorectal cancer	Mouse intestine	CFTR	↓ Wnt activity Wnt target genes	Modulation of the intracellular pH	Down	Strubberg et al., 2018
Colorectal cancer	Cell lines; Mouse models	ClC-2	↓ Wnt activity	Stabilization of β-cat at the plasma membrane	Down	Jin et al., 2018
Gastric cancer	Human sample, mouse model, Cell lines	TRPV4	↑ Wnt activity	Ca2+ → AKT → β-cat accumulation	Up	Xie et al., 2017
Prostate cancer	Cell lines	TRPM4	↑ Wnt activity	Ca2+ → AKT → β-cat accumulation	Up	Sagredo et al., 2018
Prostate cancer Breast cancer	Cell lines	TRPM8	↑ Wnt activity	Wnt ligands binding → calcium	Up	Ashmore et al., 2019
Colorectal cancer	Cell lines	TRPC5	↑ Wnt activity	Ca2+ → AKT → β-cat accumulation	Up	Wang et al., 2015
osteosarcoma	Cell lines	P2X7	↑ Wnt activity	AKT →GSK3 β → β-cat accumulation	Up	Zhang et al., 2019
Liver cancer	Human sample, Cell lines	ASIC1a	↑ Wnt activity	Modulation of β-cat phosphorylation and accumulation	Up	Jin et al., 2017