Table 1.

Regions of Highest IBD Rate in UK Biobank White British Analysis

Chromosome	Peak position (Mb)	Region (Mb)a	Max IBD %	Notesb
2	135.78	135.05–138.42 (2q21-22)	0.1702	LCT (136.55–136.59) is known to be subject to recent positive selection48
3	47.60	45.18–53.19 (3p21)	0.0264	chemokine receptor genes including CCR9 (45.93–45.94) and CXCR6 (45.98–45.99); this region shows adaptive introgression from Neanderthals49
3	123.44	122.36–124.69 (3q21)	0.0251	ADCY5 (123.00–123.17) is under long-term balancing selection50
4	38.84	38.25–40.18 (4p14)	0.0270	Toll-like receptor genes including TLR1, TLR6, and TLR10 (38.77–38.86); this locus is known to be under positive selection51
5	33.89	32.66–34.57 (5p13)	0.0262	SLC45A2 (33.94–33.98, previously known as MATP) is a pigmentation gene that has undergone recent positive selection in Europe52
6	24.87	24.01–28.96	0.0267	MHC locus containing HLA genes (28.48–33.45) is known to be subject to strong selection53
	33.96	32.70–36.27 (6p21-22)	0.0298
6	106.33	105.97–107.31 (6q21)	0.0271	PRDM1 (106.53–106.56); this locus shows a signal of recent selection54
12	53.59	52.62–54.60 (12q13)	0.0260	Type II Keratins (KRT1-8; 52.63–53.32); this locus has experienced adaptive introgression from Neanderthals55
12	113.46	111.64–114.11 (12q24)	0.0316	OAS locus (OAS1-3) (113.34–113.45); this locus has experienced adaptive introgression from Neanderthals56
15	31.59	30.76–32.58 (15q13)	0.0542	TRPM1 (31.29–31.45), a pigmentation gene under selection in non-Africans57
17	44.75	42.17–45.88 (17q21)	0.0274	17q21.31 MAPT inversion (43.44–44.85);c H2 form has been positively selected in Europe58
22	22.56	21.68–22.99 (22q11)	0.0267	UBE2L3 (21.90–21.98) is associated with multiple auto-immune diseases59

Regions in which the maximum IBD percentage is at least 0.025% are shown. Positions are in GRCh37 coordinates.

^aRegion in which the IBD rate is at least 80% of the value at the peak.

^bSee the main text for further notes and references. Genes listed within this column are contained with the region given in the third column.

^cPositions from Zody et al.⁶⁰ lifted over from build 36 (chromosome 17: 40.80–42.20 Mb) to build 37.