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. 2020 Sep 29;11:01221. doi: 10.3389/fphar.2020.01221

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Copyright © 2020 Alberto, da Silva Ferreira, Soares and Alves

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three-dimensional structures of the closed and open (ATP-bound) P2X4 states. (A, B) Crystal structure of the zfP2X4 (PDB code 4DW0) in different views, apo and open, with the transmembrane helices colored according to the subunit colors in blue, yellow, and green. ATP molecules are displayed as a van der Waals representation. (C) The same structure as in (A), viewed from the top along the axis of the central channel. (D) The same structure as in (B), seen from the top along the axis of the central channel, with ATP bound to the pharmacophore site.