Table 2.
Risk factors associated with death for patients with COVID-19 undergoing invasive mechanical ventilation.
| Univariable OR (95% CI) | P-value | Multivariable OR (95% CI) | P-value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age, years | 1.05 (1.00–1.10) | 0.049 | 1.03 (0.97–1.09) | 0.343 |
| Male sex (vs. female) | 0.74 (0.27–1.93) | 0.547 | ||
| P/F pre–intubation, mmHg | ||||
| P/F | 0.97 (0.95–0.99) | 0.002 | 0.97 (0.95–0.99) | 0.006 |
| Laboratory results at post–intubation day 3, median (IQR) | ||||
| Platelet count, × 109.L−1 | ||||
| >100 | 0.47 (0.15–0.38) | 0.175 | ||
| <100 | 2.13 (0.72–6.48) | 0.175 | ||
| AST/ALT | ||||
| ≥1 | 5.13 (1.80–15.83) | 0.003 | ||
| <1 | 0.19 (0.06–0.56) | 0.003 | ||
| BUN, mmol.L−1 | ||||
| ≥8.2 | 2.16 (0.65–7.60) | 0.215 | ||
| <8.2 | 0.46 (0.13–1.54) | 0.215 | ||
| Creatinine, μmol.L−1 | ||||
| ≥133 | 2.86 (0.73–14.29) | 0.154 | ||
| <133 | 0.35 (0.70–1.37) | 0.154 | ||
| BNP, pg.ml−1 | ||||
| ≥100 | 4.00 (1.28–13.46) | 0.019 | ||
| <100 | 0.25 (0.07–0.78) | 0.019 | ||
| TnI, ng.L−1 | ||||
| ≥26.2 | 11.00 (3.05–48.37) | <0.001 | ||
| <26.2 | 0.09 (0.02–0.33) | <0.001 | ||
| Complications | ||||
| Cardiac injury | 8.04 (2.95–24.95) | <0.001 | 15.60 (4.20–74.43) | 0.001 |
| Liver injury | 4.33 (1.69–12.04) | 0.003 | 5.40 (1.46–23.56) | 0.016 |
| Kidney injury | 8.42 (2.56–38.38) | 0.002 | 8.39 (1.63–61.41) | 0.019 |
Data are Odds Ratios (95% CI). P < 0.05 was considered statistically significant. P/F, PaO2/FiO2 ratio; ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; BNP, brain natriuretic peptide; TnI, troponin I.