Table 2.
Clinical characteristics by quartiles of serum Tsukushi levels in hyperthyroid subjects.
| Variables | Serum Tsukushi level | P-value for trend§ | |||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
| Sample size | 44 | 45 | 46 | 45 | |
| Serum Tsukushi (ng/ml)a | 105.29 (84.85–123.77) | 157.20 (143.81–166.15)‡ | 219.48 (201.93–256.79)‡ | 391.49 (349.20–452.07)‡ | <0.001 |
| Age (years) | 34.2 ± 11.0 | 31.9 ± 10.4 | 34.1 ± 10.0 | 33.9 ± 10.6 | 0.705 |
| Gender (female n, %) | 31 (70.5) | 31 (68.9) | 32 (69.6) | 31 (68.9) | 0.998 |
| BMI (kg/m2) | 20.4 ± 2.6 | 21.1 ± 4.4 | 20.6 ± 2.7 | 19.8 ± 2.6 | 0.213 |
| Systolic BP (mmHg) | 120.7 ± 13.5 | 122.1 ± 17.9 | 122.8 ± 14.8 | 124.6 ± 15.0 | 0.683 |
| Diastolic BP (mmHg) | 71.8 ± 10.6 | 71.6 ± 10.5 | 72.8 ± 10.9 | 70.9 ± 11.5 | 0.883 |
| Heart rate (beats/minute) | 100.4 ± 16.4 | 102.1 ± 16.1 | 105.2 ± 20.1 | 111.2 ± 14.1‡ | 0.005 |
| BMR (%) | 38.21 ± 19.30 | 41.98 ± 24.32 | 44.14 ± 23.20 | 53.86 ± 19.60‡ | 0.006 |
| Triglycerides (mmol/L) | 0.88 (0.70–1.16) | 0.88 (0.62–1.36) | 0.94 (0.81–1.11) | 0.87 (0.72–1.06) | 0.516 |
| Total cholesterol (mmol/L) | 3.64 ± 0.69 | 3.56 ± 0.90 | 3.95 ± 0.89 | 3.32 ± 0.64 | 0.007 |
| LDL- cholesterol (mmol/L) | 1.86 ± 0.55 | 1.85 ± 0.65 | 2.08 ± 0.73 | 1.74 ± 0.47 | 0.071 |
| HDL-cholesterol (mmol/L) | 1.33 ± 0.27 | 1.23 ± 0.40 | 1.37 ± 0.34 | 1.17 ± 0.28 | 0.086 |
| Fasting glucose (mmol/L) | 5.19 ± 0.73 | 5.09 ± 0.64 | 5.22 ± 0.82 | 5.08 ± 0.47 | 0.799 |
| HOMA-IRa | 1.60 (1.15–2.05) | 1.22 (0.73–2.00) | 1.48 (0.80–3.26) | 1.36 (1.00–2.16) | 0.724 |
| Free T3(pmol/ml)a | 12.57 (4.93–24.60) | 17.21 (8.85–28.06) | 22.57 (11.10–98.97) | 29.51 (21.98–145.53)‡ | <0.001 |
| Free T4(pmol/ml)a | 49.55 (28.83–81.47) | 59.90 (37.11–76.59) | 66.93 (45.54–86.68)† | 69.01 (51.93–85.96)‡ | 0.011 |
| TSH (mIU/L)a | 0.00 (0.00–0.01) | 0.01 (0.00–0.01) | 0.01 (0.00–0.01) | 0.01 (0.01–0.01) | 0.338 |
| TPOAb (IU/ml)a | 19.95 (5.17–248.20) | 54.22 (6.46–193.70) | 9.06 (4.98–101.27) | 16.81 (5.00–119.07) | 0.492 |
| TGAb (IU/mL)a | 12.51 (2.49–58.88) | 26.47 (7.72–182.10) | 17.84 (10.21–112.26) | 23.60 (14.43–150.87)‡ | 0.050 |
| TRAb (IU/L)a | 14.26 (1.55–24.31) | 18.82 (6.82–27.48) | 17.17 (10.31–23.74) | 18.00 (9.03–29.81)‡ | 0.015 |
BMI, body mass index; BP, blood pressure; LDL, low density lipoprotein; HDL, high density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; T3, triiodothyronine; T4, thyroxine; TSH, thyroid stimulating hormone; TPOAb, thyroid peroxide antibody; TGAb, thyroglobulin antibody; TRAb, thyrotropin receptor antibody; BMR, basal metabolic rate.
Data are presented as the mean ± SD or median (interquartile range).
§
Adjusted for age and gender.
†
P <0.05 compared with Q1 of serum Tsukushi.
‡
P <0.01 compared with Q1 of serum Tsukushi.
a
Analysis performed on log-transformed data. Two-sided values of P <0.05 were considered statistically significant.