Table 4.

Odds ratios of hyperthyroidism according to serum Tsukushi levels.

	OR	95% CI	P-value
Model 1
Serum Tsukushi (ng/ml)	1.014	1.009–1.019	<0.001
Serum Tsukushi (ng/ml)
(Quartile 2 vs. Quartile 1)	1.032	1.017–1.047	<0.001
(Quartile 3 vs. Quartile 1)	1.022	1.014–1.030	<0.001
(Quartile 4 vs. Quartile 1)	1.012	1.008–1.017	<0.001
Model 2
Serum Tsukushi (ng/ml)	1.014	1.009–1.019	<0.001
Serum Tsukushi (ng/ml)
(Quartile 2 vs. Quartile 1)	1.031	1.017–1.046	<0.001
(Quartile 3 vs. Quartile 1)	1.022	1.014–1.030	<0.001
(Quartile 4 vs. Quartile 1)	1.012	1.007–1.016	<0.001
Model 3
BMI (kg/m2)	0.856	0.701–1.046	0.129
Fasting glucose (mmol/L)	1.918	0.839–4.387	0.123
HOMA-IR	0.815	0.608–1.091	0.170
LDL-cholesterol(mmol/L)	0.063	0.025–0.159	<0.001
Serum Tsukushi (ng/ml)	1.012	1.005–1.019	0.001
Serum Tsukushi (ng/ml)
(Quartile 2 vs. Quartile 1)	1.043	1.010–1.078	0.011
(Quartile 3 vs. Quartile 1)	1.028	1.013–1.044	<0.001
(Quartile 4 vs. Quartile 1)	1.009	1.004–1.015	0.002

OR, odds ratio; CI, confidence interval; BMI, body mass index; HOMA-IR, homeostasis model assessment of insulin resistance; LDL, low density lipoprotein.

Model 1: without adjustment.

Model 2: adjusted for age, gender.

Model 3: adjusted for model 2 + BMI, fasting glucose, HOMA-IR, and LDL-cholesterol. Two-sided values of P <0.05 were considered statistically significant.