Table 5.
Effect of thionamide treatment on serum Tsukushi levels in hyperthyroid patients.
| Variables | Before | After | P-value |
|---|---|---|---|
| Sample size | 46 | 46 | |
| Age (years) | 31.6 ± 11.1 | – | – |
| Gender (female n, %) | 34 (73.9) | – | – |
| Current smokers (n, %) | 4 (8.5) | 3 (6.4) | <0.001 |
| BMI (kg/m2) | 20.3 ± 2.8 | 21.4 ± 2.7 | <0.001 |
| Waist circumference (cm) | 75.0 ± 8.5 | 77.2 ± 7.06 | <0.001 |
| Systolic BP (mmHg) | 123.4 ± 15.8 | 116.6 ± 14.0 | 0.001 |
| Diastolic BP (mmHg) | 72.7 ± 11.7 | 73.9 ± 9.8 | 0.511 |
| Heart rate (beats/minute) | 104.0 ± 11.4 | 82.1 ± 8.0 | <0.001 |
| Triglycerides (mmol/L)a | 0.87 (0.71–1.06) | 1.05 (0.74–1.33) | 0.130 |
| Total cholesterol (mmol/L) | 3.72 ± 0.84 | 5.40 ± 0.99 | <0.001 |
| LDL- cholesterol (mmol/L) | 1.88 ± 0.57 | 3.26 ± 0.77 | <0.001 |
| HDL-cholesterol (mmol/L) | 1.42 ± 0.42 | 1.62 ± 0.33 | 0.001 |
| Fasting glucose (mmol/L) | 5.26 ± 0.63 | 5.03 ± 0.44 | 0.013 |
| HOMA-IRa | 1.63 (1.13–2.57) | 1.68 (1.14–1.93) | 0.290 |
| ALT (U/L) | 36.8 ± 15.0 | 22.3 ± 13.0 | <0.001 |
| AST (U/L) | 28.6 ± 11.3 | 20.9 ± 7.2 | <0.001 |
| Free T3 (pmol/L)a | 21.23 (14.60–100.23) | 4.58 (3.83–5.40) | <0.001 |
| Free T4 (pmol/L)a | 67.16 (40.15–82.01) | 13.05 (11.60–15.39) | <0.001 |
| Total T3 (nmol/L)a | 7.63 (5.29–12.32) | 1.55 (1.28–2.15) | <0.001 |
| Total T4 (nmol/L)a | 379.00 (268.80–387.00) | 94.60 (79.75–110.95) | <0.001 |
| TSH (mIU/L)a | 0.01 (0.00–0.01) | 0.49 (0.01–3.66) | <0.001 |
| TPOAb (IU/ml)a | 26.70 (5.68–127.20) | 52.17 (5.84–299.15) | 0.253 |
| TGAb (IU/mL)a | 32.69 (10.21–243.08) | 22.31 (12.99–152.46) | 0.949 |
| TRAb (IU/L)a | 17.39 (7.64–28.28) | 8.40 (2.24–17.69) | <0.001 |
| BMR (%) | 43.32 ± 14.33 | 13.78 ± 11.74 | <0.001 |
| Serum Tsukushi (ng/ml)a | 188.52 (138.73–361.41) | 93.01 (73.80–120.68) | <0.001 |
BMI, body mass index; BP, blood pressure; LDL, low density lipoprotein; HDL, high density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; ALT, alanine transaminase; AST, aspartate aminotransferase; T3, triiodothyronine; T4, thyroxine; TSH, thyroid stimulating hormone; TPOAb, thyroid peroxide antibody; TGAb, thyroglobulin antibody; TRAb, thyrotropin receptor antibody; BMR, basal metabolic rate.
Data are presented as the mean ± SD or median (interquartile range).
a
Analysis performed on log-transformed data. Two-sided values of P <0.05 were considered statistically significant.