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Complement cascade activation in COVID-19. There was significant endothelial and subendothelial microvascular deposition of C3d, C4d and/or C5b-9 in all severe/fatal COVID-19 cases tested. Representative images of pulmonary and extrapulmonary complement staining is provided (Panel A = C4d heart, Panel B = C4d brain, Panel C = C4d lung and Panel D = C5b-9 liver).
