Fig. 5.

Cross- and external validation of molecular subtype predictors. A predictor of molecular subtypes was constructed for each of 11 primary tumour types, spanning 38 molecular subtypes on the TCGA dataset. (a) Per-class accuracy, (b) specificity, and (c) sensitivity of molecular subtype classifications evaluated through cross-validation (Fig. 1c). To further validate these subtype predictors, ovarian (d) and breast (e) subtype predictors were used to predict the respective molecular subtypes in two external datasets (GSE9899 and EGAS00000000083, respectively).