Fig. 5.

Interactions of gut microbiota altered by metformin. (a) Correlation networks of significantly altered genera between NC and MET based on the Wilcoxon rank-sum test. Spearman’ s absolute correlation coefficients ≥ 0.3 and P-values < 0.05 were retained. The edge width is proportional to the correlation strength. The node size is proportional to the mean abundance of the genera. Nodes with the same color are classified in the same phylogenetic phylum level. (b) Associations between significantly altered genera and significantly altered KEGG pathways in NC and MET. Spearman’ s correlation coefficients are plotted by the color of squares. The sizes of squares correspond to the significance of the P-values (the larger the square, the smaller the P-value). ∗∗∗ P < 0.001, ∗∗ P < 0.01, ∗ P < 0.05. Average relative abundance of KEGG pathways is plotted by heatmap next to visualization of correlation matrix. The names of genera and pathways enriched in MET were colored in red. The names of genera and pathways enriched in NC were colored in green. NC: normal control group; MET: metformin group.