Skip to main content
. Author manuscript; available in PMC: 2020 Oct 13.
Published in final edited form as: Cell Rep. 2020 Sep 15;32(11):108131. doi: 10.1016/j.celrep.2020.108131

Figure 3. Perinatal Rotenone Exposure Leads to Life-Long Changes in the Liver Transcriptome.

Figure 3.

(A) Venn diagram depicts the overlap of DEGs at each time point; baseline DEGs stem from comparisons between at D22.

(B) Heatmap of DEG-enriched biological pathways.

(C) SOD activities were measured in livers from control- or 10-ppm rotenone-exposed offspring; n = 4; data are means ± SD.

(D) Oxygen consumption through complex I (malate + glutamate) or II (succinate + rotenone) was determined in isolated mitochondria; n = 4; data are means ± SD.

(E) RNA-seq counts for actin, succinate dehydrogenase, and the SOD genes; data were normalized to actin.

(F) Representative immunoblot in whole liver homogenates.

(G) Animals were probed for the lipid peroxidation product 4HNE.

See also Figure S3 and Tables S2 and S3.