Skip to main content
. Author manuscript; available in PMC: 2020 Oct 13.
Published in final edited form as: Cell Rep. 2020 Sep 15;32(11):108131. doi: 10.1016/j.celrep.2020.108131

Figure 4. Differentially Methylated Regions Overlap with DEGs and Regulatory Genomic Regions.

Figure 4.

(A) Venn diagram depicts the overlap between DMRs and the DEGs based on the closest TSS.

(B-D) Overlap of DMRs with regions enriched for H3K27ac- (B), H3K4me1- (C), or DNase-hypersensitive (D) sites using ENCODE data.

(E) IPA-predicted upstream regulators of common (left) or unique (right) DEGs to the control or rotenone-fed offspring. Red arrows depict TFs also identified using HACER.

(F) Heatmap of significance scores for enriched representation of DEGs with DMRs. Arrows indicate left-shift on timing of DNA methylation relative to transcriptional changes.

See also Tables S4, S5, and S6.