Table 3.
Characteristics of 143 patients with pheochromocytoma/paraganglioma (PCC/PGL)
| Characteristics | Paraganglioma N = 37 | Pheochromocytoma N = 106 | P value |
|---|---|---|---|
| Mean age, years ± SD | 45.1 ± 15.5 | 48.5 ± 15.3 | .2516 |
| Female sex, n (%) | 22 (59.5) | 67 (63.2) | .0164 |
| Race, n (%) | .2955 | ||
| African American | 10 (27.0) | 25 (23.6) | |
| Caucasian | 23 (62.2) | 57 (53.8) | |
| Other | 4 (10.8) | 24 (22.6) | |
| Germline susceptibility gene mutation, n (%) | <.0001 | ||
| No mutation | 12 (32.4) | 41 (38.7) | |
| Not tested | 7 (18.9) | 43 (40.6) | |
| NF1 | 0 (0) | 9 (8.5) | |
| RET | 1 (2.7) | 5 (4.7) | |
| SDHB | 11 (29.7) | 0 (0) | |
| SDHD | 4 (10.8) | 1 (0.9) | |
| Variant of undetermined significance | 1 (2.7)a | 1 (0.9)b | |
| VHL | 1 (2.7) | 6 (5.7) | |
| Dominant secreted catecholamine, n (%) | .0373 | ||
| Epinephrine | 6 (16.2) | 36 (34.0) | |
| Norepinephrine | 29 (78.4) | 59 (55.7) | |
| Unknown | 1 (2.7) | 9 (8.5) | |
| Median tumor size, cm (IQR) | 4.5 (4.0, 5.8) | 4.6 (3.2, 7.5) | .4546 |
| Median PASS score (IQR) | — | 6.5 (4.0, 8.0) | — |
| Median GAPP score (IQR) N = 132 | 3.0 (3.0, 4.0) | 3.0 (2.0, 4.0) | .038 |
Bolded values indicate P ≤ 0.05.Abbreviations: SD, standard deviation; IQR, interquartile range; NF1, Neurofibromatosis 1; RET, Rearranged during transfection; SDHB, Succinate dehydrogenase subunit B; SDHD, Succinate dehydrogenase subunit D; VHL, von Hippel Lindau.
a SDHD c.T320C; p.L107P.
b TMEM127 c0.409 + 7C>T.