Table 4.
Univariate logistic regression analysis of predictors of recurrent pheochromocytoma/paraganglioma (PCC/PGL)
| Characteristics | Odds Ratio | 95% Confidence Interval | P value |
|---|---|---|---|
| Age | 0.969 | 0.945-0.994 | .0170 |
| Female sex | 1.601 | 0.744-3.445 | .2292 |
| Race | |||
| African-American | 3.819 | 0.947-15.393 | .0596 |
| Caucasian | 2.966 | 0.811-10.848 | .1004 |
| Other | Reference | — | — |
| Germline susceptibility gene mutation | |||
| No mutation | Reference | — | — |
| Not tested | 0.128 | 0.027-0.602 | .0092 |
| NF1 | <0.001 | <0.001-999.999 | .9665 |
| RET | 1.538 | 0.252-9.392 | .6407 |
| SDHB | 8.205 | 1.892-35.581 | .0049 |
| SDHD | >999.9999 | <0.001-999.999 | .9758 |
| Variant of undetermined significance | 3.077 | 0.179-52.746 | .4382 |
| VHL | 4.103 | 0.810-20.782 | .0881 |
| Dominant secreted catecholamine | |||
| Epinephrine | Reference | — | —- |
| Norepinephrine | 2.516 | 0.946-6.691 | .0645 |
| Unknown | 1.500 | 0.254-8.843 | .6542 |
| Tumor type | |||
| Pheochromocytoma | Reference | — | — |
| Paraganglioma | 6.357 | 2.736-14.767 | <.0001 |
| Tumor size, cm | 1.005 | 0.883-1.143 | .9410 |
| Ki-67 index (%) | |||
| <1 | Reference | — | — |
| 1-3 | 4.810 | 1.016-22.759 | .0477 |
| >3 | <0.001 | <0.001-999.999 | .9891 |
| PASS score | 1.128 | 0.947-1.343 | .1779 |
| GAPP score | 1.537 | 1.141-2.070 | .0047 |
Bolded values indicate P ≤ 0.05.Abbreviations: NF1, Neurofibromatosis 1; RET, Rearranged during transfection; SDHB, Succinate dehydrogenase subunit B; SDHD, Succinate dehydrogenase subunit D; VHL, von Hippel Lindau.