Table 6.
Pharmacokinetics Parameters for 99mTc-TQ-NLC After Oral and Intravenous Administrations into Rats (n=6)
| Parameters | Oral Administration | Intravenous Administration | ||
|---|---|---|---|---|
| Plasma | Blood | Plasma | Blood | |
| Tmax (h) | 4 | 4 | 0.5 | 0.5 |
| Cmax (%ID/g) | 0.413 | 0.347 | 3.284 | 2.173 |
| AUC24 (%ID/g.h) | 1.708 | 1.404 | 7.847 | 4.947 |
| AUC0-∞ (%ID/g.h) | 1.762 | 1.453 | 7.998 | 5.089 |
| AUCexp (%ID/g.h) | 3.077 | 3.384 | 1.889 | 2.788 |
| t1/2 (h) | 2.457 | 2.386 | 4.992 | 5.336 |
| CL (L/h) | 56.735 | 68.87 | 12.503 | 19.649 |
| Relative bioavailability (%) | 201.125 | 236.813 | 90.037 | 151.259 |
Abbreviations: AUC24, 24 h area under the curve concentration-time; AUC0-∞, area under the curve to infinity; AUCexp; exponential area under the curve; Cmax, the maximum concentration; CL, clearance; ID/g, injected dose per gram; h, hour; 99mTc, technetium-99m; TQ-NLC, thymoquinone-loaded nanostructured lipid carrier; Tmax, the time taken to reach the maximum concentration; t1/2, half-life.