Table 3. Blood lymphocyte subpopulations in 16 adults with IgGSD and subnormal IgG2a.
| Lymphocyte subpopulation | Adults (n = 16) |
|---|---|
| Median CD19+ B-cells/μL (range) | 248 (66, 626) |
| Subnormal CD19+ B-cells, % (n) | 0 |
| Elevated CD19+ B-cells, % (n) | 0 |
| Median CD4+ T-cells/μL (range) | 962 (57, 2271) |
| Subnormal CD4+ T-cells, % (n) | 6.3 (1) |
| Elevated CD4+ T-cells, % (n) | 12.5 (2) |
| Median CD8+ T-cells/μL (range) | 250 (111, 879) |
| Subnormal CD8+ T-cells, % (n) | 0 |
| Elevated CD8+ T-cells, % (n) | 0 |
| Median CD56+/CD16+ NK cells/μL (range) | 125 (35, 284) |
| Subnormal CD56+/CD16+ NK cells, % (n) | 0 |
| Elevated CD56+/CD16+ NK cells, % (n) | 0 |
a Abbreviations: IgGSD = Immunoglobulin G subclass deficiency; IgG2, immunoglobulin G2; NK, natural killer. Flow cytometry measurements were available in 16 patients (88.9%). Reference ranges (mean ± 2 SD) are: CD19+ B-lymphocytes 12–645 cells/μL; CD3+/CD4+ T-lymphocytes 359–1,519 cells/μL; CD3+/CD8+ T-lymphocytes 109–897 cells/μL; and CD56+/CD16+ NK cells 24–406 cells/μL. Levels are expressed as median (range). Subnormal levels and elevated levels were defined as those below and above the corresponding lower reference limits, respectively.