Table 3.
Multivariable Analysis for Women Aged Younger Than 50 Years With Stage I Grade 1 Endometrioid Endometrial Cancer (n=9,110)
| Overall Survival |
Death From Cardiovascular Disease |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Multivariable |
Multivariable |
||||||||
| n | 10-y | 20-y | HR (95% CI) | P | 10-y | 20-y | HR (95% CI) | P | |
| Age (y) | |||||||||
| 40–49 | 6,923 | 93.8 | 82.3 | 1 | 1.0 | 3.4 | 1 | ||
| 30–39 | 1,980 | 94.1 | 84.0 | 0.80 (0.66–0.98) | .034 | 1.1 | 3.7 | 0.82 (0.52–1.32) | .42 |
| Younger than 30 | 207 | 98.3 | 86.1 | 0.60 (0.33–1.10) | .10 | 0.6 | 3.9 | 0.60 (0.14–2.50) | .48 |
| Ethnicity | |||||||||
| White | 5,824 | 94.2 | 83.7 | 1 | 1.0 | 3.4 | 1 | ||
| Black | 478 | 88.8 | 73.7 | 1.81 (1.32–2.48) | <.001 | 3.7 | 8.5 | 3.75 (2.05–6.83) | <.001 |
| Hispanic | 1,427 | 94.4 | 82.4 | 1.07 (0.82–1.40) | .62 | 0.6 | 1.7 | 0.66 (0.30–1.46) | .31 |
| Asian | 950 | 94.5 | 83.4 | 0.83 (0.61–1.13) | .25 | 0.7 | 3.5 | 0.65 (0.29–1.45) | .30 |
| Others | 387 | 94.5 | 68.6 | 1.80 (1.28–2.53) | .001 | 0.8 | 4.2 | 1.76 (0.78–3.97) | .17 |
| Unknown | 44 | 100 | 100 | NA | .88 | 0 | 0 | NA | .97 |
| Marital status | |||||||||
| Single | 2,474 | 91.4 | 78.8 | 1 | 1.4 | 4.8 | 1 | ||
| Others | 6,277 | 94.8 | 84.1 | 0.68 (0.57–0.81) | <.001 | 0.9 | 3.2 | 0.79 (0.52–1.20) | .27 |
| Unknown | 359 | 94.6 | 80.3 | 0.91 (0.59–1.39) | .65 | 1.4 | 1.4 | 0.71 (0.22–2.35) | .58 |
| Registry area | |||||||||
| West | 4,987 | 93.9 | 82.6 | 1 | 0.8 | 3.5 | 1 | ||
| Central | 2,010 | 93.6 | 82.5 | 1.05 (0.86–1.28) | .66 | 1.8 | 3.8 | 0.97 (0.62–1.52) | .89 |
| East | 2,113 | 94.3 | 83.2 | 0.89 (0.71–1.10) | .27 | 0.9 | 3.4 | 0.82 (0.50–1.36) | .44 |
| Year of diagnosis | |||||||||
| 1983–1989 | 641 | 95.6 | 83.4 | 1 | 1.0 | 3.7 | 1 | ||
| 1990–1999 | 1,814 | 93.8 | 83.3 | 1.05 (0.83–1.33) | .66 | 1.4 | 4.1 | 1.04 (0.63–1.72) | .88 |
| 2000–2009 | 5,070 | 93.4 | 92.4 | 1.09 (0.83–1.43) | .55 | 1.0 | NR | 0.56 (0.29–1.09) | .09 |
| 2010–2012 | 1,585 | NR | NR | 0.40 (0.16–1.02) | .06 | NR | NR | 0.43 (0.05–3.52) | .43 |
| Stage | |||||||||
| IA | 7,894 | 94.1 | 83.1 | 1 | 1.1 | 3.5 | 1 | ||
| IB | 258 | 88.5 | 78.2 | 1.40 (0.86–2.26) | .18 | 1.5 | 9.3 | 2.12 (0.74–6.07) | .16 |
| I NOS | 958 | 93.3 | 81.3 | 1.16 (0.94–1.44) | .17 | 1.0 | 3.2 | 1.11 (0.69–1.78) | .68 |
| Tumor size (cm) | |||||||||
| 2.0 or less | 2,040 | 94.7 | 86.5 | 0.72 (0.44–1.18) | .20 | 1.2 | 4.3 | 3.28 (0.43–23.9) | .25 |
| 2.1–4.0 | 1,153 | 94.7 | 79.7 | 0.78 (0.47–1.32) | .35 | 1.3 | 3.5 | 3.03 (0.39–23.4) | .29 |
| 4.1–6.0 | 576 | 94.4 | 71.8 | 0.87 (0.48–1.57) | .64 | 0.2 | 5.1 | 2.03 (0.21–19.6) | .54 |
| Greater than 6.0 | 350 | 90.2 | 70.4 | 1 | 0.3 | 0.3 | 1 | ||
| Unknown | 4,991 | 93.6 | 82.2 | 0.86 (0.54–1.37) | .51 | 1.0 | 3.2 | 2.58 (0.35–18.6) | .35 |
| Surgery type | |||||||||
| Total, pan, simple hysterectomy | 8,147 | 94.0 | 82.7 | 1 | 1.0 | 3.5 | 1 | ||
| Supracervical, subtotal hysterectomy | 811 | 93.2 | 82.5 | 0.98 (0.77–1.24) | .87 | 0.6 | 3.0 | 0.54 (0.28–1.04) | .07 |
| Others | 152 | 92.2 | NR | 1.37 (0.64–2.90) | .42 | 3.3 | NR | 3.95 (0.94–16.6) | .06 |
| Adjuvant radiation | |||||||||
| No | 8,646 | 94.0 | 82.8 | 1 | 1.1 | 3.6 | 1 | ||
| Yes | 399 | 92.3 | 80.6 | 1.22 (0.90–1.67) | .21 | 0.7 | 3.4 | 1.09 (0.53–2.24) | .81 |
| Unknown | 65 | 97.9 | 95.3 | 0.59 (0.18–1.89) | .37 | 0 | 0 | NA | .95 |
| Ovarian conservation | |||||||||
| No | 8,076 | 93.7 | 82.0 | 1 | 1.1 | 3.7 | 1 | ||
| Yes | 1,034 | 95.6 | 88.8 | 0.73 (0.54–0.98) | .036 | 0.2 | 2.3 | 0.40 (0.17–0.91) | .029 |
HR, hazard ratio; CI, confidence interval; NA, not available; NR, patients did not reach the 10-year and 20-year follow-ups; NOS, not otherwise specified.
Data are % unless otherwise specified.
Cox proportional hazard regression models for multivariable analysis adjusted for collected covariates. All patient factors, tumor characteristics, and treatment patterns were entered in the final model.
Bold indicates a significant P value.