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. 2020 Aug 28;19(19):2538–2552. doi: 10.1080/15384101.2020.1810393

Figure 1.

Figure 1.

Propofol alleviates cell proliferation, migration, invasion and aerobic glycolysis in lung cancer in vitro. (a) Cell viability was detected using CCK-8 assay in A549 and H1299 cells treated with different concentrations of propofol (2, 4, 6, 8, and 10 µg/mL). (b) Cell viability was detected using CCK-8 assay in A549 and H1299 cells treated with 8 µg/mL propofol for 24, 48, and 72 h. A549 and H1299 cells were treated with 8 µg/mL propofol for 48 h. (c) Cell proliferation was analyzed using BrdU assay. (d,e) Cell migration and invasion were measured by transwell assay. (f,g) The glucose consumption and lactate production were determined by a glucose and lactate assay kit. (h) Extracellular acidification measurements were performed by Seahorse XF24 Extracellular Flux Analyzer. (i) Western blot was used to examine the protein expression of GLUT1, PKM2, HK2 and LDHA in A549 and H1299 cells. *P < 0.05.