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. 2020 Aug 28;19(19):2538–2552. doi: 10.1080/15384101.2020.1810393

Figure 6.

Figure 6.

MiR-455-3p is a target of FOXM1 in lung cancer cells. (a) The potential binding sites between FOXM1 and miR-455-3p were predicted through searching StarBase3.0 program. (b,c) Luciferase activity of A549 and H1299 cells co-transfected with FOXM1 3’UTR-WT or FOXM1 3’UTR-MUT and miR-455-3p mimics or miR-NC was determined by dual-luciferase reporter assay. (dg) The expression of FOXM1 in lung cancer tumor tissues and normal tissues, as well as lung cancer cell lines and normal BEAS-2B cell line was measured using qRT-PCR and western blot. (h,i) The level of FOXM1 was examined using qRT-PCR and western blot in A549 and H1299 cells treated with propofol. (j,k) The level of FOXM1 was examined using qRT-PCR and western blot in A549 and H1299 cells transfected with anti-miR-NC, anti-miR-455-3p, anti-miR-455-3p + si-NC, anti-miR-455-3p + si-FOXM1. *P < 0.05.