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. Author manuscript; available in PMC: 2020 Oct 13.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 12;20(2):763–766. doi: 10.1016/j.bmcl.2009.11.018

Table 5.

Pharmacokinetic data for compounds 1a and 11 in rats

Compds 30 mg/kg, po 30 mg/kg, iv
Cmax ng/mL T1/2 min AUC ng h/m (0-∞) BA% AUC ng h/mL (0-∞) T1/2 min CL mL/min/mL Vss mL/kg
1a 16.7a 103 74.4a 1.9 400 19.9 113 2542
12 7200 48.4 10,532 34.1 3091 11.1 16 145
a

Dose normalized AUC and Cmax to 30 mg/kg.