Table 2.
Comparison of geometric mean concentrations (GMCs) and geometric increases (n-fold) in levels of serotype-specific IgG and the opsonization index (OI) for serum samples from the 16 participants before and after the first, second, and third vaccinations.
| Serotype | Time point | GMC of IgG (µg/mL) (95% CI) | Geometric mean increase (n-fold; post/pre) | GMT of OI (95%CI) | Geometric mean increase (n-fold; post/pre) |
|---|---|---|---|---|---|
| 6B | Predose 1 | 0.85 (0.57–1.27) | 72 (31–166) | ||
| Postdose 1 | 2.00 (1.01–3.95)a | 2.34 | 527 (186–1495)a | 7.32 | |
| Predose 2 | 1.55 (0.89–2.70)b | 347 (114–1050)a | |||
| Postdose 2 | 2.50 (1.38–4.52)a,d | 1.62 | 1281 (658–2492)a,d | 3.69 | |
| Predose 3 | 1.14 (0.65–1.98) | 109 (40–300) | |||
| Postdose 3 | 1.67 (0.96–2.88)a,g | 1.46 | 895 (477–1681)a,e | 8.21 | |
| 14 | Predose 1 | 2.31 (1.37–3.89) | 59 (21–161) | ||
| Postdose 1 | 8.05 (5.91–10.96)a | 3.48 | 647 (229–1831)a | 10.97 | |
| Predose 2 | 3.17 (1.60–6.28) | 281 (106–745)a | |||
| Postdose 2 | 5.65 (3.04–10.50)a,d | 1.78 | 680 (264–1751)a,d | 2.42 | |
| Predose 3 | 4.91 (2.75–8.76)a,d | 189 (48–745)b | |||
| Postdose 3 | 9.00 (4.66–17.39)a,d,f,g | 1.83 | 562 (149–2120)a,g | 2.97 | |
| 19F | Predose 1 | 2.12 (1.55–2.91) | 24 (10–58) | ||
| Postdose 1 | 3.70 (2.62–5.22)a | 1.74 | 262 (144–477)a | 10.92 | |
| Predose 2 | 2.47 (1.63–3.73) | 104 (46–233)a | |||
| Postdose 2 | 3.88 (2.63–5.74)a,d | 1.57 | 380 (195–739)a,c,d | 3.65 | |
| Predose 3 | 2.84 (1.79–4.51) | 127 (47–348)b,e | |||
| Postdose 3 | 5.03 (2.95–8.56)a,d,g | 1.77 | 336 (140–808)a,d,g | 2.65 | |
| 23F | Predose 1 | 1.08 (0.63–1.87) | 15 (6–35) | ||
| Postdose 1 | 2.47 (1.33–4.58)a | 2.28 | 113 (40–322)a | 7.53 | |
| Predose 2 | 1.39 (0.71–2.73) | 52 (22–121)b | |||
| Postdose 2 | 1.93 (0.89–4.17) | 1.39 | 159 (74–341)a,d | 3.06 | |
| Predose 3 | 1.27 (0.74–2.17) | 17 (6–45) | |||
| Postdose 3 | 2.27 (1.19–4.32)a,e,g | 1.79 | 84 (24–291)a,g | 4.94 |
GMC: geometric mean concentration, GMT: geometric mean titer, CI: confidence interval.
dose 1: first vaccination, dose 2: second vaccination, dose 3: third vaccination, Predose 1: before first vaccination, Postdose 1: after first vaccination.
Predose 2: before second vaccination, Postdose 2: after second vaccination, Predose 3: before third vaccination, Postdose 3: after third vaccination.
Serum samples were collected 1 month before and after the first, second, and third vaccinations.
ap < .01 (vs. predose 1).
bp < .05 (vs. predose 1).
cp < .05 (vs. postdose 1).
dp < .01 (vs. predose 2).
ep < .05 (vs. predose 2).
fp < .05 (vs. postdose 2).
gp < .01 (vs. predose 3).