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. 2020 Aug 12;16(9):2042–2050. doi: 10.1080/21645515.2020.1793711

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Lethal H7N9 influenza virus challenge of mice. HLA-DR3 mice (10–12 mice/group) pre-immunized with H3N2 A/Hong Kong/4801/2014 (H3N2) at week 0 and vaccinated at weeks 8, 12 and 16 weeks with rH7 HA without adjuvant. At week 20, mice were intranasally infected with 10e+4 PFU of the A/Anhui/1/2013 H7N9) virus. Mice were monitored daily for weight loss (A and B) and viral lung titers in selected mice 4 d post challenge (C). Weight loss and lung viral titer was presented as mean± standard deviation (B and C). The weight loss data from a single survived mouse was marked as dotted line (B; preimmune and naïve groups). *p < .05, **p < .01, ***p < .001, ****p < .0001.