Table 3.

HIA titers and percent A/H3N2/Aichi virus neutralization and AH1N1 PR8 virus cross-neutralization in DRAGA female and male mice sublethally (LD₅₀)-infected with A/Aichi H3N2 virions (as per Figure 7).

DRAGA mice #	dpi	M1	M2	M3	M4	M5	F1	F2	F3	F4	F5	Human sera
HIA titer to Aichi virus	10	1:20	1:20	1:20	1:20	1:20						1:320**
	16						1:40	1:40	1:40	1:120*	1:120*
Percent of Aichi virus neutralization	10	16	16	16	16	16
	16						33	33	33	100	100
HIA titer to PR8 virus	10	1:20	1:40	1:20	1:20	1:20						1:560**
	16						1:40	1:40	1:40	1:60*	1:60*
Percent of PR8 virus cross-neutralization	10	33	66	33	33	33
	16						66	66	66	100	100

M1-M5, male mice assessed at 10 dpi, and F1-F5 female mice assessed at 16 dpi. * Highest HIA titer to Aichi virus, and, respectively, to PR8 virus among all mice in each group. Percent viral neutralization and cross-neutralization among individual mice was calculated based on the highest HIA titer to AICHI, or the highest HIA titer to PR8 viruses at 10 dpi for male mice, and, respectively, 16 dpi for female mice. ** HIA titers of a vaccinated individual with 2014 AFLUVIA vaccine and assessed in 2015.