Table 4.
HIA serum titers and percent virus neutralization in DRAGA mice sublethally (LD50)-infected with A/H3N2 Hong Kong or A/H3N2 Victoria virions. (as per Figure 10).
| HK-infected mice # | dpi | M1 | M2 | M3 | M4 | M5 | F1 | F2 | F3 | Humans era | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIA titers | 1:40 | 1:40 | 1:40 | 1:100* | 1:100* | 1:20 | 1:20 | 1:40 | 1:320** | |||
| Percent of virus neutralization | 40 | 40 | 40 | 100 | 100 | 20 | 20 | 40 | ||||
| Victoria-infected mice # | 32 | M1 | M2 | M3 | M4 | M5 | F1 | F2 | F3 | F4 | F5 | |
| HIA titers | 1:20 | 1:20 | 1:20 | 1:20 | 1:80 | 1:20 | 1:40 | 1:40 | 1:40 | 1:120* | 1:560** | |
| Percent of virus neutralization | 32 | 16 | 16 | 16 | 16 | 66 | 16 | 33 | 33 | 33 | 100 |
M1-M5 male mice and F1-F3 female mice infected with Hong Kong virus and assessed at 32 dpi; M1-M5 male mice and F1-F5 female mice infected with Victoria virus and assessed at 32 dpi. * Highest HIA titer to the virus. Percent viral neutralization among individual mice was calculated based on the highest HIA titer in each group. ** HIA titers of a vaccinated individual with 2014 AFLUVIA vaccine and assessed in 2015.