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. 2020 Jun 12;16(9):2007–2017. doi: 10.1080/21645515.2020.1756671

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© 2020 IMV Inc. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — DPX-RSV(A) induces SHe(A) specific CD4 + T cells. Subjects treated with DPX-RSV(A) (Step 1, n = 8; Step 2, n = 8), RSV(A)-Alum (Step 1, n = 8; Step 2, n = 8), or placebo (Step 1, n = 4; Step 2, n = 4). IFN-γ ELISPOT response performed using PBMC samples (A). Representative IFN-ɣ ELISPOT (B). Representative example of IFN-ɣ ELISPOT performed using PBMCs whole or CD8⁺ or CD4⁺ depleted (C). Responses to SHe(A) stimulation shown, background responses were >51 SFU per 10^⁶ PBMC. Statistics by 2way ANOVA and Tukey’s multiple comparisons test.