Table 3.
Relative change in SHeA-specific serum antibody isotypes of natural infection subjects from acute to convalescent with corresponding ELISA results and confirmation by PCR of RSV infection type.
| Isotypea |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Subject ID | RSV Strain Type | IgG1 | IgG2 | IgG3 | IgG4 | IgA | IgE | IgD | IgM | ELISAb |
| S6 | A | |||||||||
| S9 | A | ++ | + | +++ | ||||||
| S17 | A | |||||||||
| S18 | A | |||||||||
| S19 | A | |||||||||
| S28 | A | + | ||||||||
| S36 | A | + | + | + | ||||||
| S39 | A | |||||||||
| S41 | A | |||||||||
| S5 | B | + | ||||||||
| S8 | B | |||||||||
| S21 | B | |||||||||
| S29 | B | + | ||||||||
| S30 | B | + | + | |||||||
| S31 | B | + | + | |||||||
| S34 | B | |||||||||
| S37 | B | ++ | + | |||||||
| S40 | B | |||||||||
| S3 | NA | + | + | + | + | |||||
| S4 | NA | ++ | + | ++ | ||||||
| S7 | NA | |||||||||
| S11 | NA | ++ | + | + | ||||||
| S12 | NA | ++ | + | + | ||||||
| S13 | NA | + | ++ | |||||||
| S15 | NA | + | + | + | ||||||
| S16 | NA | + | ||||||||
| S20 | NA | |||||||||
| S32 | NA | |||||||||
| S33 | NA | + | ||||||||
| S35 | NA | + | + | |||||||
| S38 | NA | |||||||||
| S42 | NA | |||||||||
aIsotyping legend: Relative change from acute to convalescent: >2-fold but <10-fold (+), ≥10-fold (++), ≥100-fold (+++). Pre
existing response: >10-fold higher than the background in acute (gray shading).
bELISA legend: Relative change from acute to convalescent by OD (450 nm): <0.4 (+), >0.4 (++), >0.8 (+++). Preexisting response: >0.2 OD (450 nm) in acute (gray shading).