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. 2020 Jun 19;177(1):281–299. doi: 10.1093/toxsci/kfaa088

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Liver response in nuclear factor erythroid 2-related factor 2 (NRF2) knockout (KO) rats. Heatmap of Log10 RNA expression ratio values in liver from compound (10-mpk bardoxolone or 400-mpk ticlopidine) treated rats versus respective vehicle-treated wild type (WT) or NRF2 KO rats. Genes are arranged by signature loading coefficients [10] for NRF2 (left side of heatmap from high to low) or NRF1 (right side of heatmap from low to high). Bar plot indicates mean bioactivation liver response assay (BA-LRA) score ± SD for the respective experimental groups in the heatmap; *t test p = .002.