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. Author manuscript; available in PMC: 2020 Oct 13.
Published in final edited form as: Virology. 2019 Oct 18;539:26–37. doi: 10.1016/j.virol.2019.10.003

Table 1. Lysis of Differentiated T cell Effectors by LCMV-induced Activated NK Cells.

Top. This table represents a compilation of all of the cytotoxicity experiments done with enriched populations of day 3 LCMV-induced C57BL/6 mouse spleen leukocyte NK cells against effector T cell subsets in 4 hr cytotoxicity assays at E:T of 5:1. Values represent percent lysis observed. There was an additional experiment that was technically flawed and therefore not shown. Bottom. This is a one-way Wilcoxon analysis comparing the hierarchical data from all of the tabulated experiments, giving the p value of the cytotoxicity difference between each tested pair of targets. It shows that the Treg and Th17 cells are killed significantly more than the Th0 and Th1 cells, and that the Th2 cells are killed significantly more than the Th1 cells.

Experiment Th0 Th1 Tc1 Th2 Tc2 Th17 Treg
1 17 30
2 17 23 29
3 22 17 26 28 27 40 44
4 20 31
5 38 48
6 13 41
7 11 23 20 28 23
8 17 27 29 26 35
9 8.0 16 23 29
10 10 14 20 28
11 10 10 23 24
12 16 29 25
13 35 55 31
14 12 35 30
15 18 15 31
16 12 27 27
17 10 27 25 44 34 33 30
18 22 30 37 36
19 23 34 34 42
20 17 27 40
21 15 22 24
22 6.4 23 14 35
23 12 31 33 26
Th0 Th1 Tc1 Th2 Tc2 Th17 Treg
Th0 NA NA NA NA NA NA NA
Th1 0.00164 NA NA NA NA NA NA
Tc1 0.00142 0.13919 NA NA NA NA NA
Th2 3.97E-06 0.01622 0.36275 NA NA NA NA
Tc2 0.01374 0.11461 0.25122 0.41116 NA NA NA
Th17 2.02E-05 0.00451 0.13059 0.16217 0.45288 NA NA
Treg 5.58E-07 0.00149 0.17805 0.1916 0.44402 0.62247 NA