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. 2020 Oct 9;13:10087–10096. doi: 10.2147/OTT.S275218

Figure 1.

Figure 1

Relative expression of circ-ELF2 in GM tissues and cells and its clinical significance. (A) Clustered heatmap for differentially up- and downregulated circRNAs in GM tissue samples. (B) Hsa_circRNA_000552, hsa_circRNA_104798, hsa_circRNA_000543, and hsa_circRNA_103741 expression levels in GM tissue samples and their paired noncancerous tissue samples measured by qRT-PCR. (C) qRT-PCR for circ-ELF2 and linear ELF2 mRNA expression after treatment with actinomycin D at different time points. (D) Relative expression of circ-ELF2 and linear ELF2 mRNA after treatment with RNase R. (E) Relative expression of circ-ELF2 in GM tissues and normal tissues measured by qRT-PCR. (F, G) Kaplan–Meier analysis with Log rank test was applied to evaluate the clinical value of circ-ELF2 in GM patients. (H) Relative expression of circ-ELF2 in GM cell lines and normal cell line measured by qRT-PCR. *P < 0.05, **P < 0.01.