Figure 4. Univariable Mendelian randomization estimates for total cholesterol (odds ratio with 95% confidence interval per one standard deviation increase in lipid fraction) from polygenic analyses including all lipid-associated variants.
Figure 4—figure supplement 1. Univariable Mendelian randomization estimates for total cholesterol (odds ratio with 95% confidence interval per one standard deviation increase in lipid fraction) from polygenic analyses including all lipid-associated variants excluding self-reported outcomes.
Figure 4—figure supplement 2. Univariable Mendelian randomization estimates for total cholesterol (odds ratio with 95% confidence interval per one standard deviation increase in lipid fraction) from polygenic analyses including all lipid-associated variants excluding those with a cancer diagnosis other than the site-specific cancer under analysis.
Figure 4—figure supplement 3. Scatterplot to assess heterogeneity of genetic associations with total cholesterol (horizontal axis, standard deviation units) against genetic associations with overall cancer (vertical axis, log odds ratios).
Error bars represent 95% confidence intervals. Solid diagonal line represents the inverse-variance weighted estimate.