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. 2020 Jun 26;30(11):6042–6051. doi: 10.1007/s00330-020-06997-1

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© The Author(s) 2020

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Fig. 3 — Example of a case with histological progression. a 67-year-old men with an initial PSA value of 10.3 ng/ml and a positive transrectal ultrasound-guided biopsy (TRUS-GB) (1 of 12 cores with Gleason score 3 + 3 = 6 in 5% of the core). b Follow-up-MRI 24 months later showed a MRI lesion progress in size, a significant ADC decrease of the lesion, and a new further lesion in the prostate apex (PSA increase to 12.7 ng/ml). MR-guided biopsy revealed a Gleason score upgrade to 3 + 4 = 7 in max. 40% of the targeted biopsy cores (6 of 17 cores)