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. 2020 Oct 13;10:17153. doi: 10.1038/s41598-020-73604-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DSCA representative results of cross-correlation analysis in one subject according to baseline, occlusion, and release periods at supine posture. (a) Measurement positions of blood flow index (BFI) based on foot angiosome with four-channel DSCA probes on subject’s sole. (b) Raw BFI data. (1) Baseline period in tilt posture. (2) Posture change period. (3) Baseline period in supine posture. (4) Cuff-occlusion period in supine posture. (5) Release period in supine posture. (c) Detrended, normalized (processed), and filtered BFI with band pass filter (BPF) based on sectioned BFIs (Left: Baseline period in supine posture; Center: Cuff-occlusion period in supine posture; Right: Release period in supine posture). (d) Cross correlation analyses among four channels based on (c). (e) Maximum value and its lag time analysis in Ch.1 $\otimes$ Ch.2 relationship.