Table 7.

Mutation rates for brain region-specific gene sets in five TCGA tumors.

Region	TS	Polymorphism	Tumor	Mutated	Mutated		TS genes	Random genes		TS genes	Random genes
	Genes	Detection method	Type	TS genes	Randomized	P-value	Mutated	Mutated	P-value	Total	Total	P-value
					Control gene mean		Tumors	Tumors mean		Mutations	Mutations mean
Basal ganglia	145	Muse	GBM	122	77.1	< 0.01	139	114.77	0.12	446	308.3	0.04
Basal ganglia	145	Muse	HNSC	124	84.2	< 0.01	286	248.61	0.05	610	496.47	0.09
Basal ganglia	145	Muse	LGG	96	63.6	< 0.01	106	79.55	0.08	389	316.2	0.1
Basal ganglia	145	Muse	PCPG	10	8.7	0.23	11	9.53	0.23	12	9.89	0.21
Basal ganglia	145	Muse	KIRC	67	55.5	0.03	118	91.4	0.04	150	115.49	0.05
Cerebellum	78	Muse	GBM	68	44.9	< 0.01	154	86.21	0.01	402	207.68	0
Cerebellum	78	Muse	HNSC	69	48.4	< 0.01	293	196.33	0	703	344.58	0
Cerebellum	78	Muse	LGG	60	37.8	< 0.01	100	53.93	0.02	428	202.14	0
Cerebellum	78	Muse	PCPG	9	5.48	0.05	10	6.13	0.06	10	6.36	0.07
Cerebellum	78	Muse	KIRC	53	33.39	< 0.01	102	62.69	0	137	73.17	0
Cortex	40	Muse	GBM	34	23.5	< 0.01	49	45.57	0.32	118	103.52	0.26
Cortex	40	Muse	HNSC	36	25.4	< 0.01	126	122.54	0.35	194	176.84	0.26
Cortex	40	Muse	LGG	27	19.4	< 0.01	36	27.44	0.17	129	103.29	0.18
Cortex	40	Muse	PCPG	4	2.45	0.1	4	2.91	0.19	4	2.99	0.2
Cortex	40	Muse	KIRC	19	16.95	0.18	35	34.35	0.36	39	37.99	0.38
Hypothalamus	63	Muse	GBM	60	33	< 0.01	92	54.57	0.04	196	125.23	0.04
Hypothalamus	63	Muse	HNSC	54	36.5	< 0.01	175	135.66	0.04	298	202.4	0.03
Hypothalamus	63	Muse	LGG	44	27.4	< 0.01	56	37.39	0.04	188	134.15	0.06
Hypothalamus	63	Muse	PCPG	2	3.6	0.75	2	3.95	0.78	2	4.14	0.78
Hypothalamus	63	Muse	KIRC	28	22.54	0.01	48	41.54	0.17	55	46.45	0.16
Spinal cord	28	Muse	GBM	20	12.3	< 0.01	33	20.4	0.05	74	41.44	0.02
Spinal cord	28	Muse	HNSC	22	13.5	< 0.01	86	57.66	0.05	113	70.03	0.04
Spinal cord	28	Muse	LGG	21	9.9	< 0.01	22	12.48	0.04	77	42.4	0.02
Spinal cord	28	Muse	PCPG	1	1.1	0.3	1	1.2	0.34	1	1.2	0.34
Spinal cord	28	Muse	KIRC	11	8.21	0.12	19	15.2	0.23	21	16.01	0.17
Substantia nigra	43	Muse	GBM	33	23.4	< 0.01	61	45.25	0.11	123	98.89	0.15
Substantia nigra	43	Muse	HNSC	36	25.4	< 0.01	143	114.3	0.1	198	162.79	0.14
Substantia nigra	43	Muse	LGG	27	19.9	< 0.01	41	28.45	0.05	139	101.72	0.08
Substantia nigra	43	Muse	PCPG	2	2.74	0.5	7	3.2	0.05	8	3.28	0.03
Substantia nigra	43	Muse	KIRC	20	16.76	0.13	30	33.29	0.59	30	36.66	0.7
Kidney	20	Muse	GBM	19	13.44	0.01	18	32.43	0	34	67.57	0
Kidney	20	Muse	HNSC	20	14.07	< 0.01	56	90.82	0	62	121.02	0
Kidney	20	Muse	LGG	19	11.43	< 0.01	8	18.48	0	44	65.24	0
Kidney	20	Muse	PCPG	12	1.8	< 0.01	1	1.96	0	1	1.98	0
Kidney	20	Muse	KIRC	19	10.55	< 0.01	256	25.96	0	507	30.32	0