Table 2.
Examples of ChEMBL compounds with anti-HIV activity corresponding to the FTICR MS formulae found in the humic materials used in this study.
| Formula | Structure | EC50, μM | assay description | Ref. |
|---|---|---|---|---|
| C24H28O6 |  |
1.3 | Inhibition of HIV-1 induced CPE in CEM-SS cells | Kashman et al. (1993) |
| C22H14N2O7 |  |
0.1 | Inhibition of HIV-1 induced CPE in a cell-based assay | Yeo et al. (2005) |
| C27H21NO10 |  |
12.5 | Inhibition of HIV-1 integrase by electrochemiluminescent-based high-throughput strand transfer assay | Marchand et al. (2008) |
| 10.1 | Inhibition of HIV-1 RNase H by FRET high-throughput assay | Marchand et al. (2008) |