Table 1.
Exemplary Overview of In Vitro Preparations Used in Biohybrid Systems
Dissociated Cortical Neuron Culture (Keren and Marom, 2014) 
|
Organotypic Hippocampal Slice (Berger et al., 2012) 
|
Spinal Cord In Vitro (Joucla et al., 2016) 
|
Brainstem In Vitro (Kositsky et al., 2009) 
|
Whole Brain In Vitro (Bonifazi et al., 2013) 
|
|
|---|---|---|---|---|---|
| Amplitude | 100 μV | 100 μV | 50 μV | 10 μV | 100 mV intracellular; 500 μV LFP; 50 μV (spikes) |
| Spectrum | 150−3,000 Hz | 400−4,000 Hz | 0.08–3,000 Hz | 200−5,000 Hz | 150−8,000 Hz (spikes); 0.7–300 Hz (LFP) |
| Features | Action potentials; multi-unit activity | Action potentials; multi-unit activity | Burst activity; action potentials |
Action potentials; LFP |
Action potentials; LFP |
| Interface | MEA | MEA | Shank | Suction glass pipette | Suction glass pipette; MEA |
| Animal model | Newborn rat | Rat | Rat | Sea lamprey | Guinea pig |